Tutti conosciamo le strette correlazioni tra infiammazione e trombosi, che condividono molecole e processi. In questa sintetica rewiew sono analizzate le implicazioni coagulative dei processi flogistici, gli effetti della trombosi sullinfiammazione, il ruolo dellinfiammazione nella fibrinolisi (argomento di grande attualità) e le complesse interazioni tra piastrine e leucociti. Tutti temi di grande interesse per la medicina rigenerativa.
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We all know the close correlations between inflammation and thrombosis, which share molecules and processes. This synthetic review analyzes the coagulative implications of inflammatory processes, the effects of thrombosis on inflammation, the role of inflammation in fibrinolysis (a highly topical issue) and the complex interactions between platelets and leukocytes. All topics of great interest for regenerative medicine.
(dott. Miranda Rosario)
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Schrottmaier WC, Assinger A. The Concept of Thromboinflammation. Hamostaseologie. 2024 Feb;44(1):21-30.
pubmed.ncbi.nlm.nih.gov/38417802/
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Abstract
Inflammation and thrombosis are intricate and closely interconnected biological processes that are not yet fully understood and lack effective targeted therapeutic approaches. Thrombosis initiated by inflammatory responses, known as immunothrombosis, can confer advantages to the host by constraining the spread of pathogens within the bloodstream. Conversely, platelets and the coagulation cascade can influence inflammatory responses through interactions with immune cells, endothelium, or complement system. These interactions can lead to a state of heightened inflammation resulting from thrombotic processes, termed as thromboinflammation. This review aims to comprehensively summarize the existing knowledge of thromboinflammation and addressing its significance as a challenging clinical issue.
Thieme. All rights reserved.
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Keywords
thromboinflammation – immunothrombosis – platelets – coagulation – leukocytes – complement
.
We all know the close correlations between inflammation and thrombosis, which share molecules and processes. This synthetic review analyzes the coagulative implications of inflammatory processes, the effects of thrombosis on inflammation, the role of inflammation in fibrinolysis (a highly topical issue) and the complex interactions between platelets and leukocytes. All topics of great interest for regenerative medicine.
(dott. Miranda Rosario)
.
Schrottmaier WC, Assinger A. The Concept of Thromboinflammation. Hamostaseologie. 2024 Feb;44(1):21-30.
pubmed.ncbi.nlm.nih.gov/38417802/
.
Abstract
Inflammation and thrombosis are intricate and closely interconnected biological processes that are not yet fully understood and lack effective targeted therapeutic approaches. Thrombosis initiated by inflammatory responses, known as immunothrombosis, can confer advantages to the host by constraining the spread of pathogens within the bloodstream. Conversely, platelets and the coagulation cascade can influence inflammatory responses through interactions with immune cells, endothelium, or complement system. These interactions can lead to a state of heightened inflammation resulting from thrombotic processes, termed as thromboinflammation. This review aims to comprehensively summarize the existing knowledge of thromboinflammation and addressing its significance as a challenging clinical issue.
Thieme. All rights reserved.
.
Keywords
thromboinflammation – immunothrombosis – platelets – coagulation – leukocytes – complement
